Minneapolis St. Paul Mental Health Blog

Mental Health | A new study suggests young people who are hooked on their smartphones may be at an increased risk for depression and loneliness.

University of Arizona investigators designed the study to explore whether reliance on smartphones precedes symptoms of depression and loneliness, or whether the reverse is true.

Mental Health | An intermittent fasting diet may be beneficial for reducing body mass index (BMI) and improving glycemic control...

Mental Health | Teens with positive family relationships may be less likely to develop depression ....

It's the latest study to show that food can influence mental health.

Mental Health | People with binge eating disorder (BED) are at increased risk of suicidal ideation and suicide attempt…..

Smoking Increases the odds of repeated suicide attempt in people With Bipolar Disorder.

Mental Health | People with bipolar disorder who smoke tobacco, whether or not they have other substance use disorders, are at a higher risk of repeating a suicide attempt, according to a study published in the Journal of Affective Disorders.

Mental Health | A recently published report describes the case of a 35-year-old male patient who experienced a sudden elevation in his international normalized ratio (INR)

...due to an interaction between warfarin and cannabis and highlights the importance of close monitoring of patients who use these agents concomitantly.

The patient, who had a past medical history of unprovoked left leg deep vein thrombosis, ST-segment elevation myocardial infarction, and attention-deficit/hyperactivity disorder (ADHD), had been stable on warfarin 10mg daily from 2010 to 2018. His INR goal was reported to be 2.5, with an accepted range of 2.0-3.0.

At an INR follow-up appointment at a family medicine clinic in July 2018, the patient presented with an elevated INR of 7.2 but denied any symptoms of bleeding. “Upon further questioning, he reported smoking and ingesting cannabis for the past month at the recommendation of his psychiatrist for anxiety and ADHD,” the authors explained. The patient stated that he had been using cannabis edibles “almost daily” but denied any other medication or lifestyle changes.

After the patient was instructed to discontinue all cannabis use and continue warfarin 10mg daily after holding 2 doses, his INR decreased to 1.2. Over the following 3.5 months, the patient’s INR consistently trended between 3 and 4, which the authors attributed to multiple dose adjustments as well as other confounding factors (ie, diet alterations, international travel).

“The elevation in INR can be explained by the inhibition of CYP2C9 by cannabis use causing decreased metabolism of warfarin,” the authors explained. “The interaction between warfarin and cannabis was determined to be probable using the Horn Drug Interaction Probability Scale.”

Based on their findings, the authors recommended that INR be closely monitored in warfarin-treated who are initiated on cannabis, although additional large-scale studies are needed to better understand the magnitude of this interaction.

Mental Health | The lifetime prevalence of a substance use disorder (SUD) hovers around 20% in the general population. The lifetime prevalence of chronic pain is about the same.

Rates of both are much higher, however, in the psychiatric patient population.

Mental Health | Exercise is effective for both preventing and treating depression,

Mental Health | For more than 50 years, researchers have examined the effect of a ketogenic diet on patients with behavioral health disorders.