Mental Health | Risk of Serotonin Toxicity treating Migraines
Clinicians need to remain vigilant when prescribing tramadol, as its concurrent use with opioids poses a risk of serotonin toxicity.
Prescriptions of tramadol for the treatment of headache and other types of pain have increased in recent years. Because it was not scheduled as a controlled substance by the Drug Enforcement Administration until 2014, the misconception may remain that tramadol is a safer option with less risk of dependence and adverse effects compared with other opioids.